Neuroinflammation plays an important role in ischemic brain injury and recovery, however the interplay between brain development and the neuroinflammatory response is poorly understood. We previously described age-dependent differences in the microglial response and the effect of microglial inhibition.
Waisman’s stem cell research into Down syndrome gives family hope
It’s not a cure for Down syndrome that Dave Witte and Cristina Delgadillo want for their 5-year-old daughter. “Olivia is our daughter and we love her, and we love her because of who she is. …
How speaking is a lot like playing darts
Winning a game of darts requires being accurate. A player who can pick a spot on the board, focus their mind, and execute the specific motor action needed to land the bullseye will win the game. And if they miss, well, practice makes perfect.
Sigan Hartley, PhD – Slide of the Week
Parents of children with autism spectrum disorder (ASD) report elevated parenting stress. The current study examined bidirectional effects between parenting stress and three domains of child functioning (ASD symptoms, internalizing behavior problems, and externalizing behavior problems) across four time points in 188 families of children with ASD (originally aged 5 to 12 yrs).
Connecting research and clinics to help those with autism
One of the goals of the study is to discover how genetic variations in young people with ASD are related to brain changes that lead to clinical symptoms of the disorder, such as impaired social interaction and repetitive behaviors.
“If you think about it, in between genes and clinical symptoms [of ASD] are changes in brain development,” says Lainhart. “Genes first impact brain development, and as a result of changes in how the brain develops, there are clinical manifestations of what we recognize as ASD.”
David Gamm, MD, PhD – Slide of the Week
Numerous protocols have been described that produce neural retina from human pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids. While nearly all such methods yield at least partial segments of highly mature-appearing retinal structure, variabilities exist within and between organoids that can change over a protracted time course of differentiation.
Waisman Center 2018: Year in review
We’re delighted to share a video highlighting many of the strides we have made over the past year. Your generous and thoughtful contributions help us continue to pioneer research and expand clinical services that benefit …
Christopher Coe, PhD – Slide of the Week
The developing immune system is an adaptive system, primed by antigens, responsive to infectious pathogens, and can be affected by other aspects of the early rearing environment, including deviations from the normal provision of parental care. We investigated whether early rearing in an institutional setting, even when followed by years living in supportive and well-resourced families, would be associated with a persistent shift in T cell profiles.
Ritalin drives greater connection between brain areas key to memory, attention
We know enough about methylphenidate – more commonly known as Ritalin – to prescribe it to mediate attention challenges. However, UW researchers aided by Waisman scientists are taking the first steps toward a deeper understanding …
Black youths less protected from antisocial behaviors than white peers
Black youths are overrepresented in the criminal justice system. Yet, says University of Wisconsin–Madison Psychology Professor James Li, they are underrepresented by research studies examining the behaviors that can lead them there, and the potential interventions to help prevent it. Most studies have focused on predominantly white adolescents.