Title: MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome Legend: Left: Models for FMRP regulation of the MDM2 and P53 pathway, which impacts adult neurogenesis and cognition. Right …
Xinyu Zhao
Experimental drug cancels effect from key intellectual disability gene in mice
A University of Wisconsin-Madison researcher who studies the most common genetic intellectual disability has used an experimental drug to reverse—in mice—damage from the mutation that causes the syndrome.
Single brain cells reveal genes controlling formation, development
In one of the first studies to “read” the genetic activity inside individual brain cells, University of Wisconsin—Madison neuroscientist Xinyu Zhao has identified the genetic machinery that causes maturation in a young nerve cell.
Fragile X proteins involved in proper neuron development
Fragile X syndrome is the most common inherited intellectual disability and the greatest single genetic contributor to autism. Unlocking the mechanisms behind fragile X could make important revelations about the brain.
Xinyu Zhao, PhD, develops “green” mouse model for Rett Syndrome
The majority of individuals with Rett syndrome are female and are considered genetically ‘mosaic’ due to random inactivation of the X-chromosome (XCI) which occurs in around half of all their cells.