The Biden administration’s loosening of restrictions on the use of fetal tissue in research will allow UW-Madison scientists to continue such studies, which opponents have tried several times to ban in Wisconsin.
The identities of enzymes: study further defines the function of a potential target for Alzheimer’s therapy
A new study from the lab of UW-Madison professor of medicine Luigi Puglielli, MD, PhD, opens a door to potential treatments for diseases of age, such as Alzheimer’s disease, by defining the roles of two enzymes that are imperative to protein production.
Bernadette Gillick, PhD, MSPT, PT – Slide of the Week
Cerebral palsy is caused by a congenital brain lesion that occurs early in life with associated motor deficits which may result in lifelong disability. The brain has high neuroplastic potential early in life, stressing the importance for therapy. Non-invasive brain stimulation (NIBS) including transcranial direct current stimulation (tDCS) may enhance pediatric rehabilitation interventions through neuroplasticity.
Susan Ellis Weismer receives 2021 Hilldale Award
Ellis Weismer is an expert on language learning disorders in children. She has contributed new insights into three major language-associated disorders: autism spectrum disorder, developmental language disorder, and children who are late to talk.
Guggenheim Fellowship awarded to Waisman investigator Seth Pollak
Dr. Seth Pollak, the College of Letters & Science Distinguished Professor of Psychology, has been named a Fellow of the John Simon Guggenheim Memorial Foundation.
Luigi Puglielli, MD, PhD – Slide of the Week
Nε-lysine acetylation in the ER is an essential component of the quality control machinery. ER acetylation is ensured by a membrane transporter, AT-1/SLC33A1, which translocates cytosolic acetyl-CoA into the ER lumen, and two acetyltransferases, ATase1 and ATase2, which acetylate nascent polypeptides within the ER lumen. Dysfunctional AT-1, as caused by gene mutation or duplication events, results in severe disease phenotypes.
Artificial intelligence can accelerate clinical diagnosis of fragile X syndrome
An analysis of electronic health records for 1.7 million Wisconsin patients revealed a variety of health problems newly associated with fragile X syndrome.
Virtual reality work earns award for acoustics researcher
Waisman researcher Ellen Peng, PhD, is the recipient of an Editor Award from the American Speech-Language Hearing Association (ASHA) for her work on the impact of room acoustics on listener comprehension. Her article “Listening Effort …
Tracy L. Hagemann, PhD – Slide of the Week
Alexander disease (AxD) is a rare neurodegenerative disorder that is caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament that is primarily expressed by astrocytes. In AxD, mutant GFAP in combination with increased GFAP expression result in astrocyte dysfunction and the accumulation of Rosenthal fibers.
Waisman CP Clinic strikes a balance
Twins Sebastian and Charlotte Sundly are quite the contrasting pair, yet they balance one another out perfectly in some interesting and unexpected ways.