Dendritic spines, the mushroom-shaped extensions along dendritic shafts of excitatory neurons, are critical for synaptic function and are one of the first neuronal structures disrupted in neurodevelopmental and neurodegenerative diseases.
Slide of the Week
Xinyu Zhao, PhD – Slide of the Week
Fragile X messenger ribonucleoprotein 1 protein (FMRP) deficiency leads to fragile X syndrome (FXS), an autism spectrum disorder.
Donna Werling, PhD – Slide of the Week
DNA libraries generated from 235 post mortem human brain samples were sequenced using 150 bp, paired end Illumina chemistry to a desired depth of 30X coverage. Reads were aligned to either the linear GRCh38 alt-free reference genome, the linear telomere to telomere hs1 reference genome, or the draft human pangenome.
Daifeng Wang, PhD – Slide of the Week
Genotypes are strongly associated with disease phenotypes, particularly in brain disorders. However, the molecular and cellular mechanisms behind this association remain elusive.
Brittany G. Travers, PhD – Slide of the Week
We want to better understand how autistic children with and without attention-deficit/hyperactivity disorder (ADHD) differed in their motor skills, sensory features, and daily living skills.
John Svaren, PhD – Slide of the Week
The most common cause of genetic neuropathy, classified as Charcot-Marie-Tooth disease, is a 1.4 Mb duplication of the PMP22 gene.
Masatoshi Suzuki, DVM, PhD – Slide of the Week
The myotendinous junction (MTJ) is an integrated structure that transduces force across the muscle-tendon boundary, making the region vulnerable to strain injury.
André Sousa, PhD – Slide of the Week
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that is centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC.
Kristin Shutts, PhD – Slide of the Week
Close peer relationships are critical to children’s and adolescents’ healthy development and well-being, yet youth sometimes struggle to make friends.
Jenny Saffran, PhD – Slide of the Week
During word learning moments, toddlers experience labels and objects in particular environments. Do toddlers learn words better when the physical environment creates contrasts between objects with different labels?