N ε-lysine acetylation within the lumen of the endoplasmic reticulum is a recently characterized protein quality control system that positively selects properly folded glycoproteins in the early secretory pathway.
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A college degree may protect against neurodegeneration in genetically at-risk populations
Obtaining a college degree may be protective against neurodegenerative symptoms in women with an elevated genetic risk.
David Gamm works to bring research and medicine into a single vision
David Gamm is adept at keeping multiple things in focus. Gamm, MD, PhD, is a Waisman investigator, director of the McPherson Eye Research Institute, and professor of ophthalmology and visual sciences. With one eye trained on patients, he treats children in the pediatric ophthalmology clinic.
Robert A. Pearce, MD, PhD – Slide of the Week
We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated field EPSPs (fEPSPNMDA) or long-term potentiation (LTP) in vitro at concentrations that block contextual conditioning in vivo. Here we tested one possible explanation for the mismatch – that the hippocampus is relatively resistant to CPP compared to other brain structures engaged in contextual fear conditioning.
The sound of the Waisman Center’s work to improve cochlear implants
The Waisman Center has been at the forefront of research on cochlear implants and hearing science for more than two decades.
WIN for the win: Wellness Inclusion Nursing helps improve quality of life of individuals with disabilities through nursing consulting
WIN is a Waisman Center Community Outreach Wisconsin (COW) program with nurses that serve as consultants for individuals with intellectual and developmental disabilities (IDD) and their families, caregivers, residential and vocational team members, and health care providers.
Ben Parrell, PhD – Slide of the Week
Sensory errors induce two types of behavioral changes: rapid compensation within a movement and longer-term adaptation of subsequent movements.
Waisman Center welcomes new investigator with a focus on early language intervention work
Alper’s path to communication sciences was not straight forward. She initially started down the biotechnology path and sprinkled in some reproductive embryology research as well. It wasn’t until she started in a voice physiology lab seeking research with more direct human interaction that she found the path she wanted to be on.
Weight loss may be early predictor of Alzheimer’s disease in Down syndrome
Unintentional weight loss in people with Down syndrome may predict the onset of Alzheimer’s disease long before typical cognitive symptoms like memory loss and dementia are apparent.
Kennedy’s other moon shot: The origins of intellectual and developmental disabilities research centers and the Waisman Center
When President Kennedy made his inaugural speech in 1961, there was no mention of initiatives on intellectual and developmental disabilities (IDDs). Yet, the efforts by his administration and the Kennedy family to improve the lives of individuals with disabilities and their families are one of their most enduring legacies. The Waisman Center, University of Wisconsin-Madison bears the indelible fingerprints of those efforts.